---
product_id: 15238219
title: "High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets"
brand: "life extension"
price: "€ 26.71"
currency: EUR
in_stock: true
reviews_count: 10
category: "Life Extension"
url: https://www.desertcart.hr/products/15238219-high-potency-optimized-folate-l-methylfolate-folic-acid-8500-mcg
store_origin: HR
region: Croatia
---

# 8500 mcg potency Cognitive enhancement Heart health support High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets

**Brand:** life extension
**Price:** € 26.71
**Availability:** ✅ In Stock

## Summary

> 🌟 Elevate your wellness journey with every tablet!

## Quick Answers

- **What is this?** High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets by life extension
- **How much does it cost?** € 26.71 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.hr](https://www.desertcart.hr/products/15238219-high-potency-optimized-folate-l-methylfolate-folic-acid-8500-mcg)

## Best For

- life extension enthusiasts

## Why This Product

- Trusted life extension brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Elevate Your Health:** Unlock the power of 8500 mcg of bioactive 5-MTHF folate for optimal wellness.
- • **Purity You Can Trust:** Non-GMO, gluten-free, and made in the USA for peace of mind.
- • **Heart & Brain Harmony:** Support cardiovascular and cognitive health with every tablet.
- • **Science-Backed Formula:** Crafted with ingredients based on rigorous scientific research.
- • **Join the Health Revolution:** Be part of a community that prioritizes health and vitality.

## Overview

Life Extension High Potency Optimized Folate offers 8500 mcg of L-methylfolate, the bioactive form of folic acid, designed to support heart and brain health while maintaining healthy homocysteine levels. This gluten-free, non-GMO, vegetarian supplement is crafted with premium ingredients and backed by scientific research, ensuring you live your healthiest life.

## Description

Since not everyone has enough of the necessary enzymatic activity necessary to convert folic acid to 5-MTHF (the active form of folate), this highly potent dose of 5-MTHF makes it easier for you to get all the health benefits of the B vitamin folate. Indeed, you get 8500 mcg of dietary folate equivalents in every tablet. High Potency Optimized Folate helps maintain already normal levels of homocysteine, an important marker of heart health, and is also good for your brain health—specifically, maintaining healthy cognition. This heart and brain health supplement is also gluten-free, non-GMO and vegetarian.

Review: Great product - Great for moods, energy, no after taste great value for the money.
Review: Delayed release effect compared to a quicker releasing 'capsule' form. - I have done a couple other reviews on l-methyl folate supplements, and I can't really repeat everything I've said, but perhaps you could look them up under my reviewer name, I'm not sure. I'll just give you the main points I made in the other reviews: And this is just my layman's advice, from the limited experience I have with the supplement and the knowledge I've gained reading about it online and from my sister, who has been taking it for over a year now. First of all, you should probably get the genetic testing done to see if you have the MTHFR mutation in the first place. That is where my sister started, and because of the results, her naturopath suggested she started taking this stuff. If you do start taking it, START WITH A LOW DOSE, and work your way up. I assumed I had the mutation, because of my sister's genetic test results she was told that both of her parents must have the mutation, and therefore all of her siblings will have it too. I decided on my own to just start with a high dose of 15mg, and I didn't have good results. It made me feel more anxious, irritated, and antsy. I dropped down to this lower dose, and still didn't feel 'right' after taking it. I then tried half, so about 4mg, and at that point I might have felt something, but for the most part I didn't feel that it really changed my life in a noticeable way, so now I don't take it at all. Either way, I recommend, and all the info I found online says the same thing, to start with a low dose, like 1mg, and then over weeks and months, and with the support of a healthcare professional of some sort, work your way up slowly until you find the right dose for you. With all that said, I can also tell you that one of my other siblings, who has had some pretty extreme mental health issues to say the least, has started taking these supplements, along with eating fish a few times a week (before they had been a vegetarian for like 20 years...), and the combination of the two things seems to REALLY effect their mental state. I can literally tell when they have run out of the supplements, their mood and attitude is so different. (I'm using they/their to try to keep it more private, as I have multiple siblings...) Good luck, I know that one day the whole 'medical field' will catch up with all this mental health and genetic testing stuff but until then we just have to try to figure out what works best for us. And the other thing I pointed out in my other reviews is that besides any supplements you might take, I think that developing consistent and healthy habits is the best thing we can do to foster a stable mental state-The basic stuff like sleep, diet, exercise, stress management, and our alcohol/drug use.

## Features

- High potency – This powerful folate supplement contains 8500 mcg of 5-MTHF folate, the bioactive form of folic acid. Choosing 5-MTHF instead of regular folic acid is a good option because not everyone can convert folate to 5-MTHF.
- Cardiovascular support – Folate is a heart-healthy B vitamin. Why? Folate helps maintain normal levels of homocysteine, a metabolic byproduct. Keeping homocysteine levels within normal range is an important biomarker for cardiovascular health.
- Cognitive health – Folate is also a “big brain” vitamin: it helps maintain cognitive health. Again, this has to do with keeping homocysteine levels within normal range, as homocysteine has also been associated with normal cognitive decline.
- Ingredients matter – We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
- Live your healthiest life – We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00V756QFK |
| Age Range Description | Adult |
| Allergen Information | Gluten Free |
| Best Sellers Rank | #24,452 in Health & Household ( See Top 100 in Health & Household ) #32 in Vitamin B9 (Folic Acid) Supplements |
| Brand | Life Extension |
| Brand Name | Life Extension |
| Color | Off White |
| Container Type | Bottle |
| Customer Reviews | 4.6 out of 5 stars 556 Reviews |
| Diet Type | Vegetarian |
| Dosage Form | Tablet |
| Flavor | Unflavored |
| Global Trade Identification Number | 00737870191339 |
| Item Dimensions | 2.09 x 2.09 x 3.73 inches |
| Item Form | Tablet |
| Item Nype Name | L-Methylfolate Supplement |
| Item Weight | 1.12 ounces |
| Manufacturer | Life Extension |
| Manufacturer Part Number | 01913 |
| Material Type Free | Gluten Free |
| Model Name | Life Extension High Potency Optimized Folate |
| Model Number | 01913 |
| Number of Items | 1 |
| Primary Supplement Type | Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt] |
| Product Benefits | Heart Health Supplements, Brain Health Supplements |
| Special Ingredients | Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt] |
| Specific Uses For Product | Heart Health Supplements, Brain Health Supplements |
| UPC | 737870191339 |
| Unit Count | 30.00 Count |

## Product Details

- **Brand:** Life Extension
- **Item Form:** Tablet
- **Primary Supplement Type:** Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt]
- **Diet Type:** Vegetarian
- **Flavor:** Unflavored

## Images

![High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets - Image 1](https://m.media-amazon.com/images/I/71UZAQa1b8L.jpg)
![High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets - Image 2](https://m.media-amazon.com/images/I/71KxWEVg9jL.jpg)
![High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets - Image 3](https://m.media-amazon.com/images/I/81oU7-NNzPL.jpg)
![High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets - Image 4](https://m.media-amazon.com/images/I/71Esw9TPwGL.jpg)
![High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets - Image 5](https://m.media-amazon.com/images/I/71jx5gvAfHL.jpg)

## Questions & Answers

**Q: Are the raw materials for this supplement from China?**
A: Raw Material for this product is sourced from Italy, however product is manufactured in the US.

Need to know about our products and ingredients … or find out how to create a regimen of nutritional supplements, diet, and exercise that’s customized for your needs? 

Call our Wellness Specialists toll-free at 1-800-226-2370. You can reach them from 8 a.m. to 1 a.m. weekdays and 9 a.m. to 1 a.m. weekends ET.

**Q: Can someone tell me how big these tablets are?**
A: About 30-50% larger than a baby aspirin.

**Q: Description says 8500 mcg.  Detailed description says 5000 mcg.  Which actual potency is correct?**
A: 500mcg

**Q: What is the difference between the white bottle and the dark blue bottle?**
A: Life Extension changed packaging from white to Blue a few months ago.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Great product
*by C***N on April 30, 2026*

Great for moods, energy, no after taste great value for the money.

### ⭐⭐⭐⭐⭐ Delayed release effect compared to a quicker releasing 'capsule' form.
*by E***B on November 9, 2024*

I have done a couple other reviews on l-methyl folate supplements, and I can't really repeat everything I've said, but perhaps you could look them up under my reviewer name, I'm not sure. I'll just give you the main points I made in the other reviews: And this is just my layman's advice, from the limited experience I have with the supplement and the knowledge I've gained reading about it online and from my sister, who has been taking it for over a year now. First of all, you should probably get the genetic testing done to see if you have the MTHFR mutation in the first place. That is where my sister started, and because of the results, her naturopath suggested she started taking this stuff. If you do start taking it, START WITH A LOW DOSE, and work your way up. I assumed I had the mutation, because of my sister's genetic test results she was told that both of her parents must have the mutation, and therefore all of her siblings will have it too. I decided on my own to just start with a high dose of 15mg, and I didn't have good results. It made me feel more anxious, irritated, and antsy. I dropped down to this lower dose, and still didn't feel 'right' after taking it. I then tried half, so about 4mg, and at that point I might have felt something, but for the most part I didn't feel that it really changed my life in a noticeable way, so now I don't take it at all. Either way, I recommend, and all the info I found online says the same thing, to start with a low dose, like 1mg, and then over weeks and months, and with the support of a healthcare professional of some sort, work your way up slowly until you find the right dose for you. With all that said, I can also tell you that one of my other siblings, who has had some pretty extreme mental health issues to say the least, has started taking these supplements, along with eating fish a few times a week (before they had been a vegetarian for like 20 years...), and the combination of the two things seems to REALLY effect their mental state. I can literally tell when they have run out of the supplements, their mood and attitude is so different. (I'm using they/their to try to keep it more private, as I have multiple siblings...) Good luck, I know that one day the whole 'medical field' will catch up with all this mental health and genetic testing stuff but until then we just have to try to figure out what works best for us. And the other thing I pointed out in my other reviews is that besides any supplements you might take, I think that developing consistent and healthy habits is the best thing we can do to foster a stable mental state-The basic stuff like sleep, diet, exercise, stress management, and our alcohol/drug use.

### ⭐⭐⭐⭐⭐ The only vitamins ANYONE should take!
*by M***H on May 5, 2024*

This vitamin is the only vitamin anyone should take daily. As it is in its most natural forms which allows the body to fully absorb it all! It's small and easy to swallow and to say I can see a difference would be an understatement! the energy levels I have are out the roof! The pull is little so it’s easy to swallow and only has a taste if you let it dissolve in your mouth. The price is average but worth it due to how well they work!

## Frequently Bought Together

- Life Extension High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets
- Life Extension Neuro-Mag Magnesium L-Threonate, Magnesium L-threonate, Memory Health, Quick Thinking, Cognitive Health Support, Vegetarian, Non-GMO, 90 Vegetarian Capsules
- Life Extension Vitamin B12 Methylcobalamin, Nerve Health Supplement, Cognitive Support, Energy Vitamin, methylcobalamin B12, 1 mg, Quick-Dissolving, Vegetarian, 60 lozenges

---

## Why Shop on Desertcart?

- 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016
- 🌍 **Shop Globally** — Access 737+ million products across 21 categories
- 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price
- 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members)
- 🔒 **Secure Payments** — Trusted payment options with buyer protection
- ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews

**Shop now:** [https://www.desertcart.hr/products/15238219-high-potency-optimized-folate-l-methylfolate-folic-acid-8500-mcg](https://www.desertcart.hr/products/15238219-high-potency-optimized-folate-l-methylfolate-folic-acid-8500-mcg)

---

*Product available on Desertcart Croatia*
*Store origin: HR*
*Last updated: 2026-05-25*