---
product_id: 168097228
title: "Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump"
brand: "differin"
price: "€ 53.38"
currency: EUR
in_stock: true
reviews_count: 9
category: "Differin"
url: https://www.desertcart.hr/products/168097228-differin-acne-retinoid-treatment-gel-0-1-adapalene-45g-pump
store_origin: HR
region: Croatia
---

# Up to 87% acne reduction in 12 weeks 0.1% Adapalene Rx-strength Oil-free, fragrance-free, non-comedogenic Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump

**Brand:** differin
**Price:** € 53.38
**Availability:** ✅ In Stock

## Summary

> 🔥 Clear skin, no filter needed.

## Quick Answers

- **What is this?** Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump by differin
- **How much does it cost?** € 53.38 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.hr](https://www.desertcart.hr/products/168097228-differin-acne-retinoid-treatment-gel-0-1-adapalene-45g-pump)

## Best For

- differin enthusiasts

## Why This Product

- Trusted differin brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Clean & Gentle Formula:** Water-based, oil-free, and fragrance-free to fit seamlessly into your daily routine without irritation.
- • **Dual-Action Acne Defense:** Targets clogged pores and inflammation simultaneously for clearer, smoother skin that stands out.
- • **Visible Results That Keep You Ahead:** Experience up to 87% fewer breakouts in just 12 weeks—because your skin deserves real transformation.
- • **Dermatologist-Trusted & Millennial-Approved:** Join thousands who trust Differin to fight acne and hyperpigmentation while refining skin texture.
- • **Prescription-Strength Power Without the Script:** Harness the clinically proven 0.1% adapalene retinoid for fast, deep pore acne defense.

## Overview

Differin Acne Retinoid Treatment Gel delivers prescription-strength 0.1% adapalene in a gentle, oil-free formula that clears, treats, and prevents acne by normalizing skin cell turnover. Clinically proven to reduce acne breakouts by up to 87% in 12 weeks, it’s the first FDA-approved OTC retinoid in over 30 years, trusted by dermatologists and perfect for acne-prone skin seeking visible, lasting results.

## Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Review: Works for hyperpigmentation - This has really helped with hyperpigmentation. I use it only at night and layer a PM moisturizer. For daytime, I use Vitamin C, moisturizer, and tinted sunscreen. The tinted sunscreen is also an important factor in this process. I used mild hydrating face cleansers daily and did a gentle exfoliation or clay mask once a week. I had some dryness and skin peeling during the first 2 weeks but that steadily improved and was pretty much gone by around day 40. What pleases me even more than the decreased hyperpigmentation is how silky smooth my entire face feels. Picture is plain face with maybe only moisturizer, but no makeup and no retouch.
Review: 1 YEAR REVIEW for Pimples and ANTI-AGING! - I am writing this review after being on Differin for 1 year. I started Differin just a few months before my 45th birthday. I had never really dove real deep into a skincare routine before. Just washing my face and using a basic retinol cream. You can see from my photos that I definitely had deep wrinkles, fine lines, uneven tone, texture, and dry skin especially under my eyes, occasional breakouts, blackheads, large pores, and some scars from popping pimples. I still don’t have a real complicated skin care routine now. I’m just starting to add more active treatments, so the results in the photos are primarily Differin and moisturizer. I have to say what gets me the most are my under eyes and lips in these photos. Because retinoids migrate up to 2 inches when absorbed, I didn’t really use a separate treatment product on my eyes or lips. Just a cream and lip balm. I got the idea to use Differin AKA Adapalene from watching Dr. Maren Locke (The Budget Dermatologist) on YouTube. She said it’s a great budget option for a powerful retinoid that’s prescription strength when you’re dealing with wrinkles but still breakout. If you haven’t seen her videos I highly recommend you check them out. Especially the ones about Differin and how to introduce it to your skin. I followed her instructions to a T and I’m glad I did! Don’t think that if you’ve used retinol for a while you’re safe from irritation. I wasn’t, this stuff is Retinoic Acid just a little more gentle than Tretinoin. It does not have to make any conversions in your skin before it gets to work. Unlike retinol- 2 conversions and retinal- 1 conversion. It is strong!! And it absolutely works for pimples and everything else I mentioned above. I do not regret trying this and giving my skin the time it needed to adjust completely (it took about 8 wks). During your adjustment period I strongly suggest you put aside anything with Hyaluronic Acid in it. It will pull the Differin deeper into your skin and can increase irritation. Also maybe lay off other actives if you can. Sunscreen is an MUST and my skin did not like chemical sunscreens during this period. I had redness during this time and increased sensitivity to the sun. I didn’t have too much peeling but my skin definitely liked moisturizer. Here’s what I used to help adjust and keep the irritation low and bearable. Morning: Vanicream gentle facial cleanser (pump), La Roche-Posay Toleraine Double Repair Moisturizer, Australian Gold mineral tinted sunscreen spf 50. Night: same cleanser, then I used the sandwich method for applying the differin. I used the same moisturizer, applied the differin, then applied more moisturizer. Doing this really helped me! My result photos: I’m gonna give full disclosure so you can make an informed decision about this product. My before photo was taken during the day, indoors with the light on. I was also about 30 pounds heavier than I am now. Yay! My 1 year later photos I am almost 46, they were taken at night but indoors with the light on. My skin looks red but it’s not. That’s just the lighting difference. Both photos are just straight up my skin, up close and personal lol. I’m not wearing makeup nor had I done my nighttime routine yet. I also don’t have any lip balm on. It’s just me. Before picture is on the left and 1 year on the right. My forehead photo before is on the bottom and 1 year on the top. I’m also going to try to find an adjustment period photo. It won’t be split and I am super red. I will without a doubt continue to use this as my retinoid everyday. The only way I’d stop is if I was able to get Tretinoin. THIS STUFF WORKS and it’s AFFORDABLE!

## Features

- TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
- THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B07ZTN5N1V |
| Active Ingredients | Adapalene 0.1% |
| Best Sellers Rank | #305 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #1 in Facial Skin Care Sets & Kits |
| Brand | Differin |
| Brand Name | Differin |
| Container Type | Bottle |
| Customer Reviews | 4.6 out of 5 stars 10,545 Reviews |
| Global Trade Identification Number | 00302994910403 |
| Item Form | Gel |
| Item Type Name | Retinoid |
| Item Weight | 45 g |
| Manufacturer | Galderma |
| Manufacturer Part Number | 0299.491040 |
| Material Features | Fragrance Free, Non-Comedogenic |
| Model Number | 0299.491040 |
| Package Size Name | 90 Day Supply |
| Product Benefits | Anti-Acne |
| Scent | Unscented |
| Scent Name | Unscented |
| Set Name | Style/Size Set |
| Size | 45g (90 Day Supply) |
| Skin Type | Acne-Prone, Combination, Normal |
| Special Ingredients | Retinoid |
| Target Use Body Part | Face |
| UPC | 302994910403 |
| Unit Count | 1.6 Ounce |

## Product Details

- **Brand:** Differin
- **Item Form:** Gel
- **Product Benefits:** Anti-Acne
- **Scent:** Unscented
- **Skin Type:** Acne-Prone, Combination, Normal

## Images

![Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump - Image 1](https://m.media-amazon.com/images/I/61G3FDAnC8L.jpg)
![Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump - Image 2](https://m.media-amazon.com/images/I/71fDFNicRgL.jpg)
![Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump - Image 3](https://m.media-amazon.com/images/I/71OSA3HfJ+L.jpg)
![Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump - Image 4](https://m.media-amazon.com/images/I/81ydkBYo4LL.jpg)
![Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump - Image 5](https://m.media-amazon.com/images/I/71Iv5hGTucL.jpg)

## Questions & Answers

**Q: How long does it take to see results when using Differin Gel?**
A: Differin Gel is formulated with Adapalene Retinoid, which works deep into pores in 5 minutes. When consistently applied to the full face, you may start to see results in as little as 1 week with best results after 12 weeks.

**Q: Can I use Differin Gel if I have sensitive skin?**
A: Differin Gel includes Adapalene an ingredient shown to have improved tolerability resulting in less redness and skin irritation. Apply once daily to dry skin after cleansing. Stop use and consult a dermatologist if irritation becomes severe.

**Q: How often should I apply Differin Gel each day?**
A: Use once daily (AM or PM). Clean skin gently and pat dry before applying. Cover the entire face with a thin layer. Do not use more than once a day. Applying more than directed will not provide faster or better results and may worsen skin irritation.

**Q: Can I use moisturizer with Differin Gel?**
A: Moisturizing is essential in supporting the skin barrier when using Differin Gel and can help to combat excessive dryness or irritation. Apply Differin Gel to clean, dry skin then follow with non-comedogenic moisturizer and SPF in the AM.

**Q: Does Differin Gel cause purging or make acne worse before it gets better?**
A: Acne may appear to worsen within the first few weeks of use as Differin Gel accelerates skin cell turnover. Continue treatment as directed; symptoms should subside between weeks 2-4. If severe irritation occurs stop use and consult dermatologist.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Works for hyperpigmentation
*by L***A on July 29, 2026*

This has really helped with hyperpigmentation. I use it only at night and layer a PM moisturizer. For daytime, I use Vitamin C, moisturizer, and tinted sunscreen. The tinted sunscreen is also an important factor in this process. I used mild hydrating face cleansers daily and did a gentle exfoliation or clay mask once a week. I had some dryness and skin peeling during the first 2 weeks but that steadily improved and was pretty much gone by around day 40. What pleases me even more than the decreased hyperpigmentation is how silky smooth my entire face feels. Picture is plain face with maybe only moisturizer, but no makeup and no retouch.

### ⭐⭐⭐⭐⭐ 1 YEAR REVIEW for Pimples and ANTI-AGING!
*by K***R on July 24, 2026*

I am writing this review after being on Differin for 1 year. I started Differin just a few months before my 45th birthday. I had never really dove real deep into a skincare routine before. Just washing my face and using a basic retinol cream. You can see from my photos that I definitely had deep wrinkles, fine lines, uneven tone, texture, and dry skin especially under my eyes, occasional breakouts, blackheads, large pores, and some scars from popping pimples. I still don’t have a real complicated skin care routine now. I’m just starting to add more active treatments, so the results in the photos are primarily Differin and moisturizer. I have to say what gets me the most are my under eyes and lips in these photos. Because retinoids migrate up to 2 inches when absorbed, I didn’t really use a separate treatment product on my eyes or lips. Just a cream and lip balm. I got the idea to use Differin AKA Adapalene from watching Dr. Maren Locke (The Budget Dermatologist) on YouTube. She said it’s a great budget option for a powerful retinoid that’s prescription strength when you’re dealing with wrinkles but still breakout. If you haven’t seen her videos I highly recommend you check them out. Especially the ones about Differin and how to introduce it to your skin. I followed her instructions to a T and I’m glad I did! Don’t think that if you’ve used retinol for a while you’re safe from irritation. I wasn’t, this stuff is Retinoic Acid just a little more gentle than Tretinoin. It does not have to make any conversions in your skin before it gets to work. Unlike retinol- 2 conversions and retinal- 1 conversion. It is strong!! And it absolutely works for pimples and everything else I mentioned above. I do not regret trying this and giving my skin the time it needed to adjust completely (it took about 8 wks). During your adjustment period I strongly suggest you put aside anything with Hyaluronic Acid in it. It will pull the Differin deeper into your skin and can increase irritation. Also maybe lay off other actives if you can. Sunscreen is an MUST and my skin did not like chemical sunscreens during this period. I had redness during this time and increased sensitivity to the sun. I didn’t have too much peeling but my skin definitely liked moisturizer. Here’s what I used to help adjust and keep the irritation low and bearable. Morning: Vanicream gentle facial cleanser (pump), La Roche-Posay Toleraine Double Repair Moisturizer, Australian Gold mineral tinted sunscreen spf 50. Night: same cleanser, then I used the sandwich method for applying the differin. I used the same moisturizer, applied the differin, then applied more moisturizer. Doing this really helped me! My result photos: I’m gonna give full disclosure so you can make an informed decision about this product. My before photo was taken during the day, indoors with the light on. I was also about 30 pounds heavier than I am now. Yay! My 1 year later photos I am almost 46, they were taken at night but indoors with the light on. My skin looks red but it’s not. That’s just the lighting difference. Both photos are just straight up my skin, up close and personal lol. I’m not wearing makeup nor had I done my nighttime routine yet. I also don’t have any lip balm on. It’s just me. Before picture is on the left and 1 year on the right. My forehead photo before is on the bottom and 1 year on the top. I’m also going to try to find an adjustment period photo. It won’t be split and I am super red. I will without a doubt continue to use this as my retinoid everyday. The only way I’d stop is if I was able to get Tretinoin. THIS STUFF WORKS and it’s AFFORDABLE!

### ⭐⭐⭐⭐⭐ Reliable Long-Term Acne Treatment That Works With Consistent Use
*by L***S on January 26, 2026*

I’ve been using Differin Gel for years, and it’s a staple in my routine. This is one of the few acne treatments I consistently repurchase because it actually helps when used correctly and patiently. Differin works by regulating skin cell turnover, so results are gradual rather than overnight. If you’re starting for the first time or restarting after a long break, it’s normal to experience an initial breakout phase as your skin adjusts. In my experience, this settles with continued, consistent use, and overall breakouts become less frequent and less severe over time. The gel itself is lightweight, fragrance-free, and easy to incorporate into an evening routine. A thin layer goes a long way. I also find it’s best used as part of a simple, gentle skincare routine, especially since this type of product can make skin feel more sensitive at first. I keep this on hand at all times and reorder it regularly. One downside is that the price fluctuates on Amazon, so I usually wait to restock when it drops. Overall, this is a solid option for anyone looking for a long-term acne treatment rather than a quick fix. It takes patience, but it’s been very reliable for me over the years. Pros: - Effective with consistent, long-term use - Lightweight, non-greasy gel - Fragrance-free and easy to layer into a routine -One pump lasts a long time Cons: - Adjustment period can cause temporary breakouts - Skin may feel more sensitive at first - Price fluctuates

## Frequently Bought Together

- Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)
- PanOxyl Acne Foaming Wash Benzoyl Peroxide 10% Maximum Strength Antimicrobial, 5.5 Oz
- Differin Acne Face Wash with 5% Benzoyl Peroxide, Daily Deep Cleanser by the makers of Differin Gel, Gentle Skin Care for Acne Prone Sensitive Skin, 4 oz (Packaging May Vary)

---

## Why Shop on Desertcart?

- 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016
- 🌍 **Shop Globally** — Access 737+ million products across 21 categories
- 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price
- 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members)
- 🔒 **Secure Payments** — Trusted payment options with buyer protection
- ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews

**Shop now:** [https://www.desertcart.hr/products/168097228-differin-acne-retinoid-treatment-gel-0-1-adapalene-45g-pump](https://www.desertcart.hr/products/168097228-differin-acne-retinoid-treatment-gel-0-1-adapalene-45g-pump)

---

*Product available on Desertcart Croatia*
*Store origin: HR*
*Last updated: 2026-08-03*