---
product_id: 254644750
title: "K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary)"
brand: "k9 advantix"
price: "€ 111.35"
currency: EUR
in_stock: true
reviews_count: 5
category: "K9 Advantix"
url: https://www.desertcart.hr/products/254644750-k9-advantix-ii-large-dog-vet-recommended-flea-tick-mosquito
store_origin: HR
region: Croatia
---

# For dogs 21-55 lbs Waterproof after 24 hours Kills fleas in 12 hours K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary)

**Brand:** k9 advantix
**Price:** € 111.35
**Availability:** ✅ In Stock

## Summary

> 🐾 Stay ahead of pests—because your dog deserves the best defense!

## Quick Answers

- **What is this?** K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary) by k9 advantix
- **How much does it cost?** € 111.35 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.hr](https://www.desertcart.hr/products/254644750-k9-advantix-ii-large-dog-vet-recommended-flea-tick-mosquito)

## Best For

- k9 advantix enthusiasts

## Why This Product

- Trusted k9 advantix brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Effortless Application:** Fragrance-free, topical treatment that’s quick and mess-free
- • **No Prescription Needed:** Convenient OTC availability so your dog stays protected without hassle
- • **Rapid Flea Elimination:** Kills fleas within 12 hours to stop infestations fast
- • **All-in-One Pest Defense:** Repels and kills fleas, ticks, mosquitoes, biting flies & lice on contact
- • **Vet-Recommended Protection:** Trusted formula to prevent flea-borne diseases and discomfort

## Overview

K9 Advantix II Large Dog is a vet-recommended, fragrance-free topical treatment designed for dogs 21-55 lbs. It kills fleas within 12 hours and repels ticks, mosquitoes, biting flies, and lice on contact. Waterproof after 24 hours, this easy-to-apply formula requires no prescription and provides a 2-month supply to keep your dog protected indoors and outdoors.

## Description

K9 Advantix II Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die. Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia. That’s why K9 Advantix II Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21-55 lbs. to use K9 Advantix II Large Dog. For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park. K9 Advantix II Large Dog is a trademark of Elanco or its affiliates.

Review: Quick & Effective - I read, researched & wanted to pull my hair out! I got my grand dog & needed something quick to combat fleas! This was #3 on the list I found & desertcart had it!! It arrived next day, easy application! It worked immediately and effectively! It came in a 2pk for a great value!
Review: It works - My dog was on a prescription medication before this. I had to stop her previous medication because it was out of stock for a while and when it was restocked, the price skyrocketed to $250 for a 6 month supply instead of the usual $120 that it was prior. There was a new generic version of her prescription but after reading the reviews on that, I didn’t want to risk my dog’s health. During that time of her not being on any preventative, we ended up with a flea problem in my area which we never had before. Since the fires, a lot of wildlife has been dropping by in my neighborhood and with wildlife comes fleas just hitching a ride with them. We fell victim to an infestation in our backyard and surrounding areas. I panicked and tried the holistic approach for months with DE, changing my dog’s diet, essential oils, etc to no avail. I had to try something because my dog is old and I really didn’t want to stress her by taking her to the vet for yet another prescription (which all had extremely negative adverse effects after doing plenty of research). I decided to try an OTC flea treatment and it was between this one and frontline. After doing more research, I opted for Advantix II since it was more effective than frontline (for my area). So glad I did because fleas were gone within a day. My dog has been on this for a year now and so far it is working. I did find a flea on her the other day right after we got back inside from our little walk and was able to grab it. I put it in a ziplock bag with a piece of my dogs shedded fur just to see if the treatment was still working since it had been 26 days since I used Advantix and within 2 hours of that flea crawling on her fur in that bag, it was dead. So I know for sure that this medication is working and working effectively at that. She was groomed two days prior to me finding a flea on her as well (she had a waterless bath and is wiped down with her dog wipes daily) - the bath and wipes didn’t minimize the effectiveness of this flea medication which is a huge plus! What I’ve learned throughout this whole process is that no treatment is going to immediately kill or prevent fleas or ticks - not even prescription medication - Advantix has saved me hundreds if not thousands of dollars on prescriptions and it’s still as effective as a prescription. It’s a win - win in my book and I will continue to use this year round to keep my dog protected.

## Features

- K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Kills fleas within 12 hours of application
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
- No prescription needed

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00N7DEBN4 |
| Active Ingredients | Imidacloprid, Permethrin, Pyriproxyfen |
| Age Range Description | 7 weeks and older |
| Allergen Information | Allergen-Free |
| Best Sellers Rank | #59,997 in Pet Supplies ( See Top 100 in Pet Supplies ) #73 in Dog Flea Drops |
| Brand | K9 Advantix |
| Brand Name | K9 Advantix |
| Customer Reviews | 4.4 out of 5 stars 16,136 Reviews |
| Dog Breed Size | Large |
| Item Form | Topical |
| Item Type Name | Topical |
| Item Weight | 0.1 Ounces |
| Item form | Topical |
| Item volume | 5 Milliliters |
| Item weight | 0.1 Ounces |
| Manufacturer | K9 Advantix |
| Manufacturer Part Number | 86314940 |
| Model Number | 86314940 |
| Scent | Unscented |
| Scent Name | Unscented |
| Target Species | Dog |
| UPC | 724089060716 |
| Unit Count | 2 Count |
| Volume | 5 Milliliters |

## Product Details

- **Active Ingredients:** Imidacloprid, Permethrin, Pyriproxyfen
- **Brand:** K9 Advantix
- **Item form:** Topical
- **Item weight:** 0.1 Ounces
- **Scent:** Unscented

## Images

![K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary) - Image 1](https://m.media-amazon.com/images/I/71TEm2OCbGL.jpg)

## Customer Reviews

### ⭐⭐⭐⭐ Quick & Effective
*by M***R on 25 May 2026*

I read, researched & wanted to pull my hair out! I got my grand dog & needed something quick to combat fleas! This was #3 on the list I found & Amazon had it!! It arrived next day, easy application! It worked immediately and effectively! It came in a 2pk for a great value!

### ⭐⭐⭐⭐⭐ It works
*by A***R on 10 June 2025*

My dog was on a prescription medication before this. I had to stop her previous medication because it was out of stock for a while and when it was restocked, the price skyrocketed to $250 for a 6 month supply instead of the usual $120 that it was prior. There was a new generic version of her prescription but after reading the reviews on that, I didn’t want to risk my dog’s health. During that time of her not being on any preventative, we ended up with a flea problem in my area which we never had before. Since the fires, a lot of wildlife has been dropping by in my neighborhood and with wildlife comes fleas just hitching a ride with them. We fell victim to an infestation in our backyard and surrounding areas. I panicked and tried the holistic approach for months with DE, changing my dog’s diet, essential oils, etc to no avail. I had to try something because my dog is old and I really didn’t want to stress her by taking her to the vet for yet another prescription (which all had extremely negative adverse effects after doing plenty of research). I decided to try an OTC flea treatment and it was between this one and frontline. After doing more research, I opted for Advantix II since it was more effective than frontline (for my area). So glad I did because fleas were gone within a day. My dog has been on this for a year now and so far it is working. I did find a flea on her the other day right after we got back inside from our little walk and was able to grab it. I put it in a ziplock bag with a piece of my dogs shedded fur just to see if the treatment was still working since it had been 26 days since I used Advantix and within 2 hours of that flea crawling on her fur in that bag, it was dead. So I know for sure that this medication is working and working effectively at that. She was groomed two days prior to me finding a flea on her as well (she had a waterless bath and is wiped down with her dog wipes daily) - the bath and wipes didn’t minimize the effectiveness of this flea medication which is a huge plus! What I’ve learned throughout this whole process is that no treatment is going to immediately kill or prevent fleas or ticks - not even prescription medication - Advantix has saved me hundreds if not thousands of dollars on prescriptions and it’s still as effective as a prescription. It’s a win - win in my book and I will continue to use this year round to keep my dog protected.

### ⭐⭐⭐⭐⭐ This Works Fast!!!!!
*by C***E on 21 April 2026*

I actually couldn’t wait to write this review- As soon as I put this on my tic infested dogs and rubbed it around- two fell off and were dead!!!!

## Frequently Bought Together

- K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary)
- K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply
- K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 2-Mo Supply

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*Product available on Desertcart Croatia*
*Store origin: HR*
*Last updated: 2026-06-07*