---
product_id: 51457228
title: "Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules"
brand: "zylkene"
price: "€ 105.37"
currency: EUR
in_stock: true
reviews_count: 13
category: "Zylkene"
url: https://www.desertcart.hr/products/51457228-zylkene-calming-supplements-for-large-dogs-30-to-60kg-450mg
store_origin: HR
region: Croatia
---

# natural alpha casozepine for large dogs 30-60kg 450mg potent calming dose Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules

**Brand:** zylkene
**Price:** € 105.37
**Availability:** ✅ In Stock

## Summary

> 🐾 Calm, collected, and confidently yours — because your big buddy deserves peace of mind!

## Quick Answers

- **What is this?** Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules by zylkene
- **How much does it cost?** € 105.37 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.hr](https://www.desertcart.hr/products/51457228-zylkene-calming-supplements-for-large-dogs-30-to-60kg-450mg)

## Best For

- zylkene enthusiasts

## Why This Product

- Trusted zylkene brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Tailored for Large Dogs:** Precisely dosed 450mg capsules designed for dogs weighing 30-60kg to ensure effective relief
- • **Versatile Stress Support:** Ideal for fireworks, social events, travel, or any short-term stressful situation—keep your dog calm anywhere
- • **Effortless Administration:** Unflavored capsules easily sprinkled on food for stress relief without the hassle
- • **Vet-Trusted Calming Power:** UK’s No.1 veterinary calming supplement trusted by professionals and pet parents alike
- • **Natural & Clinically Proven:** Harnesses alpha casozepine, a natural milk protein clinically shown to reduce stress and anxiety

## Overview

Zylkene Calming Supplements deliver a clinically proven 450mg dose of natural alpha casozepine per capsule, expertly formulated for large dogs (30-60kg). Trusted as the UK’s top veterinary calming aid, it supports pets through short-term stressors like loud noises and social gatherings. Easy to administer and allergen-free, this 20-capsule pack offers convenient, vet-approved relief to help your dog stay relaxed and happy wherever life takes you.

## Description

From the manufacturer UK's No.1 veterinary* calming supplement Contains casein, a natural milk protein with clinically proven calming effects Helps pets cope with challenging situations inside or outside the home

Review: OMG I cant praise this enough - If I could give this ten stars I would ! We have an old dog suffering from dementia. He is physically in excellent health but was suffering from severe stress and a condition named Sundown which was very horrible for him. He would become seriously agitated at night and pace in circles wimping. During the day he hardly responded and his eyes looked vacant and dull. We were at the point of having him pts. I remembered using the equine version on a horse and it worked to settle him in competition. So I gave it a go not really very hopefull. Within two days he was more settled. He continued to improve and has been on it now for a month and the Sundown no longer bothers him. His eyes are bright and he is now enjoying life. No longer dragging on walks and his appetite is healthy again. He is still an old dog but a normal old dog. No longer stressed and confused. No pacing and staring. I cant beleive the difference we have our dog back. He is fed the dose for a large dog although he is a labrador and med.
Review: Life saver - For my older dog, who had symptoms very much like dementia, these have made such a difference. He did have episodes during the day, but night time was always the worst. He would wake up panting, pacing around, anxious, and nothing I did seemed to settle him. It could last the entire night. Since trying these, the change has been amazing. We’re all finally sleeping through the night again, with no constant pacing or barking. They are pricey, but for the peace and a full night’s sleep, they’ve been worth every penny.

## Features

- Calming Supplement for Large Dogs: Zylkene (450mg) is a calming supplement for large dogs (30 to 60kg) to help them cope with short-term challenging situations such as fireworks and social gatherings
- Trusted by Professionals: UK's No. 1 Veterinary Calming Supplement, widely used and trusted by vets, behaviourists and pet owners (Kynetec market data, MAT May 2023)
- Versatile Use: Suitable for challenging situations inside and outside the home so cats and dogs can feel calm wherever they are
- Natural Active Ingredient: Contains alpha casozepine, a natural milk protein with clinically proven calming properties
- Easy Administration: Can easily be sprinkled on to your pet's food and absorbed internally providing action for pets in and out of the home
- Convenient Pack Size: Contains 20 capsules providing support for your large dog during stressful situations and challenging events

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00K06M9QC |
| Age Range Description | Adult |
| Age range (description) | Adult |
| Allergen Information | Allergen-Free |
| Benefits | Brain Health Support |
| Best Sellers Rank | 582 in Pet Supplies ( See Top 100 in Pet Supplies ) 26 in Relaxants & Anxiety Relief for Dogs |
| Brand | Zylkene |
| Brand Name | Zylkene |
| Colour | White & Blue |
| Country Of Origin | France |
| Customer Reviews | 4.1 out of 5 stars 4,332 Reviews |
| Dosage Form | Capsule |
| Flavour | Unflavoured |
| Included Components | nil |
| Item Dimensions | 6 x 6 x 17 centimetres |
| Item Form | Capsule |
| Item Nype Name | Relaxants & Anxiety Relief for Large Dogs |
| Item Weight | 450 Milligrams |
| Item form | Capsule |
| Manufacturer | Vetoquinol |
| Manufacturer Contact Information | Vetoquinol UK Ltd, Steadings Barn, Pury Hill Business Park, Nr Alderton, Towcester, Northamptonshire NN12 7LS |
| Manufacturer Part Number | 3605874361775 |
| Model Name | Zylkene |
| Model Number | 3605874361775 |
| Number of Items | 1 |
| Primary Supplement Type | Casein |
| Primary supplement type | Casein |
| Product Warranty | 2 year manufacturer |
| Product benefits | Brain Health Support |
| Specific Uses For Product | Behaviour |
| Supplement Formulation | Individual Supplement |
| Unit Count | 20.0 count |

## Product Details

- **Brand:** Zylkene
- **Flavour:** Unflavoured
- **Item form:** Capsule
- **Primary supplement type:** Casein
- **Product benefits:** Brain Health Support

## Images

![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 1](https://m.media-amazon.com/images/I/71hWFQgX5nL.jpg)
![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 2](https://m.media-amazon.com/images/I/71W65hGXErL.jpg)
![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 3](https://m.media-amazon.com/images/I/71tHQqd+0yL.jpg)
![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 4](https://m.media-amazon.com/images/I/71dUKTHJl5L.jpg)
![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 5](https://m.media-amazon.com/images/I/616wZP8AcsL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: What is the best time to give**
A: Zylkene is suitable for both short- and long-term use. 
For short term use we recommend you begin administration 1 or 2 days before the predicted stressful event. For long term use, give Zylkene to your pet every day for a month then reassess their needs and continue if needed.
We recommend talking to your vet if it is a long-term problem to make sure there are no underlying issues.

We hope this information was useful! The Zylkene Team.

**Q: Why is The packaging is all in foreign?**
A: If it is a foreign supplier, I imagine the info will not be in English, I always search for UK seller.

**Q: I have a 4 month old kitten is it safe to give her these please?**
A: My kitten is 2 mouths old and my vet prescribed me this medication for him . Unfortunately I didn’t see any difference yet .

**Q: How long does it take to work?**
A: used to calm our dog before going to the groomers , started 3 days before our appointment giving 2 tablets daily . Originally prescribed by our vet and those were dosage recommended

## Customer Reviews

### ⭐⭐⭐⭐⭐ OMG I cant praise this enough
*by A***T on 25 March 2026*

If I could give this ten stars I would ! We have an old dog suffering from dementia. He is physically in excellent health but was suffering from severe stress and a condition named Sundown which was very horrible for him. He would become seriously agitated at night and pace in circles wimping. During the day he hardly responded and his eyes looked vacant and dull. We were at the point of having him pts. I remembered using the equine version on a horse and it worked to settle him in competition. So I gave it a go not really very hopefull. Within two days he was more settled. He continued to improve and has been on it now for a month and the Sundown no longer bothers him. His eyes are bright and he is now enjoying life. No longer dragging on walks and his appetite is healthy again. He is still an old dog but a normal old dog. No longer stressed and confused. No pacing and staring. I cant beleive the difference we have our dog back. He is fed the dose for a large dog although he is a labrador and med.

### ⭐⭐⭐⭐⭐ Life saver
*by N***N on 12 May 2026*

For my older dog, who had symptoms very much like dementia, these have made such a difference. He did have episodes during the day, but night time was always the worst. He would wake up panting, pacing around, anxious, and nothing I did seemed to settle him. It could last the entire night. Since trying these, the change has been amazing. We’re all finally sleeping through the night again, with no constant pacing or barking. They are pricey, but for the peace and a full night’s sleep, they’ve been worth every penny.

### ⭐⭐⭐⭐ Short term solution
*by B***Y on 22 September 2024*

I brought this for my girl dog when her brother unfortunately passed and she was so upset. Seems to be having some effect but did not help during a storm last night. Maybe needs to build up in the system before full effect is reached

## Frequently Bought Together

- Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pet Anxiety | Helps Pets cope with short-term challenging situations | Easily administered | 20 capsules
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*Product available on Desertcart Croatia*
*Store origin: HR*
*Last updated: 2026-07-29*