--- product_id: 543984741 title: "Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml)" brand: "isdin" price: "€ 354.68" currency: EUR in_stock: true reviews_count: 8 category: "Isdin" url: https://www.desertcart.hr/products/543984741-isdinceutics-retinal-advanced-rejuvenating-facial-night-serum-with-retinaldehyde-melatonin store_origin: HR region: Croatia --- # 43% wrinkle reduction in 4 weeks Night serum with melatonin for skin rejuvenation Dual-phase tech for ingredient stability Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml) **Brand:** isdin **Price:** € 354.68 **Availability:** ✅ In Stock ## Summary > 🌟 Wake up to younger, radiant skin — because aging gracefully is the new power move. ## Quick Answers - **What is this?** Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml) by isdin - **How much does it cost?** € 354.68 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.hr](https://www.desertcart.hr/products/543984741-isdinceutics-retinal-advanced-rejuvenating-facial-night-serum-with-retinaldehyde-melatonin) ## Best For - isdin enthusiasts ## Why This Product - Trusted isdin brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Nighttime Skin Renewal:** Infused with melatonin to support your skin’s natural overnight repair cycle—wake up glowing, every day. - • **Advanced Dual-Phase Formula:** Innovative two-phase technology locks in potency, ensuring every drop delivers maximum anti-aging power. - • **Clinically Proven Youth Boost:** Clinically shown to reduce wrinkles by 43% in just 4 weeks—because your skin deserves results, not promises. - • **Hydrating & Radiance-Enhancing:** Boosts hydration and evens skin tone for a subtle, enviable glow that says you’re on top of your skincare game. - • **Gentle Yet Effective Retinaldehyde:** Powerful retinoid action that smooths texture and firms skin, tested safe even for sensitive skin types. ## Overview ISDIN Isdinceutics Retinal Advanced is a 50ml rejuvenating night serum formulated with retinaldehyde and melatonin. Clinically proven to reduce wrinkles by 43% in 4 weeks, it uses a dual-phase technology to maintain ingredient stability and is suitable for all skin types, including sensitive skin. This serum smooths skin texture, improves firmness, and enhances radiance while supporting natural overnight skin repair. ## Description Discover ISDIN products Visit the Store Discover ISDIN products Visit the Store Review: First Retinoid Product - so far so good! - I’ve never used retinal/retinol etc, so using this product is my very first attempt. I am 40+, fair skin, sensitive skin, dry skin, med/large pores, still prone to hormonal breakouts, some sun damage freckling, pretty deep 11s, and very minor wrinkles anywhere else. I started using this right around 2/1/24. It’s now 2 months of almost nightly use since (I’ve skipped a couple nights here or there just from schedule issues). I do use a full 2 pumps each time, every night, and I run the excess down my neck and upper chest to help with signs of aging there. I thought FOR SURE I would have bad peeling, redness, etc because I have sensitive skin and usually EVERYTHING makes me red or break out. But this hansy been bad at all! I started to think that might mean it’s a dud product, but I have been going thru “purge” for about 3-4 weeks. Not constant, but a couple of rounds of very agitated pimples. Moreso than I usually get, and I am used to have them every month with my cycle. So that makes me feel like it’s doing SOMETHING! I think I may be on the downward slope of the purge…. Hopefully. How does my skin feel or look? Well, it actually does feel more hydrated and softer than ever. I love that! It looks slightly more even tone (between the breakout areas when I’m having pimples and generally all over when I’m not having a breakout.) I also feel like I’m seeing a little more radiance or glow. Nothing miraculous, but just a little more shine and luster. I have not noticed a reduction in my deep 11s or my 2 very fine forehead lines. So far I’m happy. It’s such an expensive product I hate that you have to spend so much to find out if it works, but I feel like the signs I’m seeing now support continued use and expense. At 2 months, it looks to me like I might have 1 month of product left in the jar. For the price I paid, if it lasts 3 months, that’s about $62 a month ($744 a year!). I’ve never had an rx from a derm, so I’m not sure how that compares to prescription and office visit costs. I’m going to continue trying this for the full year. If I feel confident that I’m seeing results, I’ll do a cost comparison of actually getting on and maintaining a retinoid rx or just continuing this product. Will update! Review: I love it - Value for money, effectiveness, excellent texture. ## Features - YOUR SOLUTION FOR: Fine lines and wrinkles, loss of elasticity and firmness, dullness - KEY INGREDIENT: A very effective retinoid, retinaldehyde demonstrates powerful youth-boosting properties - ACTION: Smoothes skin texture for visibly younger-looking skin - TESTED: Advanced formula tested for all skin types, including sensitive skin - TECHNOLOGY: Separates ingredients into two phases to keep formula stable and effective - RESULTS: Clinical results show -43% of wrinkles after 4 weeks ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B0CC9W3VWR | | Brand | ISDIN | | Brand Name | ISDIN | | Customer Reviews | 4.4 out of 5 stars 215 Reviews | | Item Volume | 1.7 Fluid Ounces | | Manufacturer | ISDIN | | Manufacturer Part Number | 690023835 | | Product Benefits | Dermatologist Recommended | | Recommended Uses For Product | Wrinkles | | Skin Tone | All | | Skin Type | All | | Special Ingredients | Vitamin E | | Target Use Body Part | Skin | | Unit Count | 1.7 Fluid Ounces | | Use for | Skin | ## Product Details - **Age Range (Description):** Adult - **Brand:** ISDIN - **Item Volume:** 1.7 Fluid Ounces - **Number of Items:** 1 - **Skin Type:** All ## Images ![Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml) - Image 1](https://m.media-amazon.com/images/I/71ykLlogFDL.jpg) ## Questions & Answers **Q: Is Retinal Advanced suitable for sensitive skin?** A: Yes! It’s suitable for all skin types. Retinal Advanced has been clinically tested on a wide range of skin types, including sensitive skin **Q: Can I use it day and night?** A: The use of retinoids can make the skin more sensitive to external factors, meaning that the effect of sun exposure can be more intense. For this reason, we recommend using it at night, followed by a broad spectrum sunscreen in the morning. **Q: Can I use it at any time of the year?** A: Yes, once your skin is retinized, you can use Retinal Advanced at night all year round. No matter the time of year: always apply sun protection the next morning! ## Customer Reviews ### ⭐⭐⭐⭐⭐ First Retinoid Product - so far so good! *by R***L on April 6, 2024* I’ve never used retinal/retinol etc, so using this product is my very first attempt. I am 40+, fair skin, sensitive skin, dry skin, med/large pores, still prone to hormonal breakouts, some sun damage freckling, pretty deep 11s, and very minor wrinkles anywhere else. I started using this right around 2/1/24. It’s now 2 months of almost nightly use since (I’ve skipped a couple nights here or there just from schedule issues). I do use a full 2 pumps each time, every night, and I run the excess down my neck and upper chest to help with signs of aging there. I thought FOR SURE I would have bad peeling, redness, etc because I have sensitive skin and usually EVERYTHING makes me red or break out. But this hansy been bad at all! I started to think that might mean it’s a dud product, but I have been going thru “purge” for about 3-4 weeks. Not constant, but a couple of rounds of very agitated pimples. Moreso than I usually get, and I am used to have them every month with my cycle. So that makes me feel like it’s doing SOMETHING! I think I may be on the downward slope of the purge…. Hopefully. How does my skin feel or look? Well, it actually does feel more hydrated and softer than ever. I love that! It looks slightly more even tone (between the breakout areas when I’m having pimples and generally all over when I’m not having a breakout.) I also feel like I’m seeing a little more radiance or glow. Nothing miraculous, but just a little more shine and luster. I have not noticed a reduction in my deep 11s or my 2 very fine forehead lines. So far I’m happy. It’s such an expensive product I hate that you have to spend so much to find out if it works, but I feel like the signs I’m seeing now support continued use and expense. At 2 months, it looks to me like I might have 1 month of product left in the jar. For the price I paid, if it lasts 3 months, that’s about $62 a month ($744 a year!). I’ve never had an rx from a derm, so I’m not sure how that compares to prescription and office visit costs. I’m going to continue trying this for the full year. If I feel confident that I’m seeing results, I’ll do a cost comparison of actually getting on and maintaining a retinoid rx or just continuing this product. Will update! ### ⭐⭐⭐⭐⭐ I love it *by M***E on January 29, 2026* Value for money, effectiveness, excellent texture. ### ⭐⭐⭐⭐⭐ Good product *by H***A on February 12, 2026* Make my skin soft ## Frequently Bought Together - ISDIN Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml) - ISDIN Eryfotona Actinica Zinc Oxide and 100% Mineral Sunscreen Broad Spectrum SPF 50+, No White Cast, Suitable for Sensitive Skin - Vitamin C and Hyaluronic Acid Serum ampoule, Flavo-C Ultraglican by ISDIN --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.hr/products/543984741-isdinceutics-retinal-advanced-rejuvenating-facial-night-serum-with-retinaldehyde-melatonin](https://www.desertcart.hr/products/543984741-isdinceutics-retinal-advanced-rejuvenating-facial-night-serum-with-retinaldehyde-melatonin) --- *Product available on Desertcart Croatia* *Store origin: HR* *Last updated: 2026-06-20*