Question 1

What percent withanolides does this product contain?

Accepted Answer

The active ingredient in ashwagandha is a group of flavonoids called withanolides, which help support the body's ability to manage stress symptoms and promote relaxation.   At this strength the breakdown is something like this:The steroidal lactones Withanone (Dry weight of the roots at 5.54+/-0.4mg/g and 18.42+/-0.8mg/g leaves14), 27-deoxywithanone (1.63+/-0.2mg/g in the leaves and 3.94+/-0.4mg/g in the roots14), and 27-hydroxywithanone (0.50+/-0.1mg/g dry weight leaf and root14)The 5,6-epoxy steroidal lactones Withaferin A15 (22.31+/-1mg/g dry weight of leaves and 0.92+/-0.4mg/g in roots14) and 17-hydroxy-27-deoxy-Withaferin A (3.61+/-0.5mg/g dry weight of leaf and 0.66+/-0.2mg/g root14)The Withanolide series of 6,7-epoxy steroidal lactones mostly looking at Withanolide A15 (root at 3.88+/-0.7mg/g, leaf at 2.11+/-0.5mg/g14) but also B-D;16 there are some variants such as 27-hydroxy Withanolide B (0.55+/-0.2mg/g root and 2.78+/-0.5mg/g dry leaf weight14)The Withanoside series of steroidal lactones, usually Withanoside IV (0.44+/-0.1mg/g in the root dry weight and 1.60+/-0.2 in the leaves14) and VI (1.90+/-0.2mg/g in the leaves and 3.74+/-0.2mg/g in the roots14) although up to 19 exist16Diepoxy variants of the withanolides such as 5β,6β,14α,15α-diepoxy-4β,27-dihydroxy-1-oxowitha-2,24-dienolide17Chloronated withanolide variants such as 27-acetoxy-4β,6α-dihydroxy-5β-chloro-1-oxowitha-2,24-dienolide1718 and Withanolide Z19Withanolide glycosides, which are referred to as Sitoindosides (or glycowithanolides)202112-deoxywithastromonolide at 2.15+/-0.5mg/g in the leaves and 1.90+/-0.5mg/g in the roots14Physagulin (3.46 ± 0.4mg/g in the leaves; not detectable in the root14) with variants (4,16-dihydroxy-5β,6β-epoxyphysagulin D22) and glycosides (27-O-β-d-glucopyranosylphysagulin D22)Ashwagandhanolide (Withaferin A dimer bound by a sulfur bridge which breaks the epoxide site, or 'thiowithanolide'),2324 the same molecule but with a sulfoxide rather than a sulfur bridge (Withanolide sulfoxide),24Viscosa lactone B16Other sulfated steroidal lactones25Kaempferol at 0.06mg/g (fruit dry weight, none in roots nor leaves)26Naringenin at 0.50mg/g in the fruit by dry weight (none in roots nore leaves)26(+)-Catechin at 12.82mg/g (roots), 19.48mg/g (fruits), and 28.38mg/g dry weight (leaves)26Gallic acid at 0.18mg/g dry weight of the leaves (none in root nor fruit)26Phenolic acids such as Syringic acid (0.30mg/g in the leaves), p-coumaric acid (0.80mg/g in the leaves), vanillic acid (0.15mg/g leaf dry weight), and benzoic acid (0.80mg/g in the leaves)26A 1,4-dioxane derivative (2,5-Dioxo-3-tetratriacont-3′-enyl-1,4-dioxane)27β-sitosterol and stigmaterol, as well as each molecule's glucoside.2814Trigonelline (1.33+/-0.3mg/g in the leaves14)Palmitic acid in the leaves (3.55+/-0.5mg/g dry weight14) and root (1.18+/-0.2mg/g dry weight14)Oleic acid in the leaves (0.71+/-0.1mg/g dry weight14) and root (0.39+/-0.1mg/g dry weight14)Linoleic acid in the leaves (1.52+/-0.2mg/g dry weight14) and roots (1.31+/-0.2mg/g dry weight14)Linolenic acid in the leaves (4.38+/-0.5mg/g dry weight14) and roots (0.15+/-0.1mg/g dry weight14)

Question 2

Does this extract compare favorably with ksm-66 or sensoril?

Accepted Answer

Sensoril uses extracts from both the leaf and roots of the ashwagandha herb, KSM-66 is only the root extract so is higher concentration full spectrum.I found the Ashwagandha Extract 500 mg which is an adaptogen (gives the body what is needs) to be very efficient. I accidentally took an extra pill and found that it felt like I had one too many drinks...coordination was off and I was woozy. So this strength in one pill does fine.

Question 3

How big are the capsules?

Accepted Answer

They're medium sized. Not so large that they're hard to swallow

Question 4

what amount of active ingredient (root extract) - 'withanolides' does this product contain?

Accepted Answer

The label information is not listed in percentages. However the only other ingredients are vegetable cellulose (capsule), silica, vegetable magnesium stearate. I believe they are a very small percentage of the total considering ingredients are generally listed in order of quantity.

ASIN	B008Y3N0YS
Age Range Description	Adult
Allergen Information	Egg Free, Fish Free, Gluten Free, Soy Free, Wheat Free
Best Sellers Rank	#51,532 in Health & Household ( See Top 100 in Health & Household ) #1,964 in Blended Vitamin & Mineral Supplements
Brand	Best Naturals
Brand Name	Best Naturals
Container Type	Bottle
Customer Reviews	4.5 out of 5 stars 5,244 Reviews
Diet Type	Gluten Free
Dosage Form	Capsule
Flavor	Unflavoured
Global Trade Identification Number	00817716011226
Is Product Expirable	Yes
Item Form	Capsule
Item Package Quantity	1
Item Weight	500 Milligrams
Manufacturer	Best Nutritionals LLC
Manufacturer Part Number	817716011226
Material Features	Genetically Modified Organism (GMO) Free
Model Number	817716011226
Number of Items	1
Package Information	Bottle
Package Quantity	1
Recommended Uses For Product	relaxing
Special Ingredients	Ashwagandha
Total Servings Per Container	120
UPC	817716011226
Unit Count	120 Count

Best Naturals Ashwagandha Capsules for Relaxing Stress and Mood, 500 mg, 120 Count (Packaging may vary)

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