

💧 Unlock 48 hours of unstoppable hydration — your skin’s new BFF!
Cetaphil Deep Hydration 48 Hour Activation Serum is a dermatologist-recommended, fragrance-free serum designed for sensitive and dry skin. Powered by the exclusive HydroSensitive complex, hyaluronic acid, and vitamins E & B5, it delivers intense hydration that lasts up to 48 hours while soothing and replenishing skin without clogging pores. Lightweight and fast-absorbing, it can be used alone or layered under moisturizers to boost skin’s moisture and improve overall texture and appearance.









| ASIN | B0957ZBGBJ |
| ASIN | B0957ZBGBJ |
| Active Ingredients | hyaluronic_acid, vitamin_e |
| Best Sellers Rank | #10,980 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #255 in Facial Serums |
| Brand Name | Cetaphil |
| Customer Reviews | 4.6 4.6 out of 5 stars (1,319) |
| Item Form | Serum |
| Item Volume | 30 Milliliters |
| Item Weight | 0.13 Pounds |
| Item model number | 0299.011700 |
| Manufacturer | Galderma |
| Manufacturer | Galderma |
| Manufacturer Part Number | 0299.011700 |
| Material Features | Fragrance Free |
| Material Type Free | Fragrance Free |
| Model Number | 0299.011700 |
| Number of Items | 1 |
| Product Benefits | Antioxidant, Hydrating, Moisturizing, Replenishing, Soothing |
| Product Dimensions | 1.68 x 1.56 x 5 inches; 2.14 ounces |
| Recommended Uses For Product | Hydrating,Provides Vitamins,Sensitivity Relief,Soothing |
| Scent Name | Unscented |
| Skin Type | Combination, Dry, Mature, Normal, Sensitive |
| Special Ingredients | Hyaluronic Acid |
| Target Use Body Part | Face |
| UPC | 302990117004 |
| UPC | 302990117004 |
| Unit Count | 1 Fluid Ounces |
V**H
Super hydrating!!!!!!
When I purchased this item, I'd been dealing with some health issues that left my skin in terrible shape (redness, dull appearance, rough texture, dry, etc). But let me tell you, the first time I used this product, it felt like the heavens opened up, the angels started singing and a light beamed down on me. 🤣 I tested it to see if my face would stay moisturized for 48 hours, and it didn't disappoint. I cleansed my face with a gentle cleanser followed by a hydrating toner. Then I applied this serum. My face didn't feel greasy. A little goes a long way. My face felt so soft and hydrated. And most of all, the redness and dullness had greatly diminished. It has a creamy texture and is fragrance free which I like because I have sensitive skin. But I have to get back to the hydration. My skin feels so plump and smooth and bouncy and shiny. I've been using it for about 6 months and it's definitely a holy grail in my skin care routine. BTW, I'm a 55 year old African American who's currently going through menopause (if that's helpful to anyone). Trust me, if you try this product, you won't be disappointed. And it's very affordable.
M**S
Moisturizer/serum
One of the best moisturizer and serums out there on the market just a little pricey though, but if I was rich, I’d buy it again and again and again
C**Y
Go to skincare
I love this lotion because it is lightweight and hydrating. There is no fragrance and it really helps with dryness. My husband even used it too. Great value compared to more expensive brands making it my go to skincare.
M**A
Good moisturizer
This is a very good facial moisturizer. So far it keeps my face soft, smooth and hydrated.
L**Z
Lightweight texture and no scent
This serum seems a little different from other face serums i have tried, in that the texture at first pump reminds me of lotion more than serum. But once rubbed in, it's very lightweight and absorbs fairly quickly. I use this with the Cetaphil Retinol serum (i'm not sure if i'm supposed to or need to, but so far no bad interactions/ side effects). The pump is easy to use and the serum is not greasy. No detectable scent.
S**B
Effective and light, not oily
I hate face lotion, but this stuff is amazing. I had a severe allergic reaction that caused my whole face to swell up, and when the swelling was going down my skin got incredibly dry and uncomfortable. I typically detest most face lotion, it feels oily and thick and I just can't stand it, but desperate times. This was probably the 6th brand I tried and man it's so good. It doesn't feel greasy or gross, it rubs in super quick and works very well, while feeling very light. I gifted this to a few family members who also have issues with lotion over Christmas, and they were also impressed. Highly recomme
S**N
My skin is loving it
Gentle and moisturizing. Makes my skin feel so great , not greasy but definitely nourished . Highly recommend Buying it again for vacation
S**N
Not worthy, not much moisturizing.
Make my skin matte , it may be good for oily skin but not good for dry skin like me as this is not that much moisturizing , can't provide enough hydration support to my dry patchy skin. This is a thin and light weight cream type product, not serum type which can provides a hydrating and moisturizing effect, but this didn't provide that much. I feel tightness and dryness even after applying it. Not recommended for dry skin people. I give it a 3 star for its skin compatibility, it do not create any irritation, bump or any damage to my skin. Well tolerated.
V**Z
Es más una formula cremosa, se absorbe rápido y me gustó mucho para preparar la piel antes del maquillaje. Mi piel es muy seca, con tendencia al eccema y sensible, si bien lo compré para el rostro me ayuda mucho para el eccema en mis manos, no se requiere mucho producto, tiene un olor extraño, pero se quita.
A**N
Tengo rosácea y me salen espinillas quisticas y con este producto me han dejado de salir y me ha bajado la irritación.
R**O
Excelente producto para mí que tengo piel sensible me sirve mucho
Z**M
Good for skin hydration.
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