Cellular and Molecular Immunology

Excellent and readable contents for physicians/ students from all fields. Slightly more elaborate for general purpose but very lucid language and diagrams.

Well written book.

Excellent, très complet, plus facile à comprendre si on a déjà des connaissances de base, adapté à médecins, pharmaciens, biologistes et bien entendu étudiants

This is a very comprehensive presentation of the immune system. It covers it in a most up to date manner for example including the most recent studies on CAR-T cells and PD-1 inhibitors. It covers each of the immune elements in detail and that includes the innate and adaptive system. Specifically: 1. The discussion of T helper cells is complete with an excellent summary and detail on each of its elements. 2. The CTL are covered in equal detail and these are critical in the understanding of current immunotherapy. 3. The complement system is covered but here I would have liked to see it more on a stand alone basis. The complement system gets limited coverage but recent work in AMD for adults seems to give it some potential. 4. Immunotherapy in a broader sense is covered but not in detail. For example there is limited inclusion of dendritic cell therapy for prostate cancer. It is not clear what this is used for, since it is so encyclopedic. I have considered it akin to a "shop manual" for immunology. It has every part and piece and it details what part is connected to what other part. However, the Immune System is a system and this system view is lacking. To understand immune system failures one must understand the basic dynamics of the immune system. This book detailed every piece and part but lacks leaving the reader with an overall system view. One can walk away with encyclopedic knowledge but not necessarily with a visceral understanding of the workings. Not withstanding my critique, this is clearly the standard for such presentation. However the Kuby Immunology series does add a dimension which is missing, namely the laboratory efforts involved in understanding where and how many of these facts were determined. I have used the Kuby books from the first addition forward and they are an excellent complement to this work. Also I have found the book by How the Immune System Works (The How it Works Series) is an excellent "road map" and system oriented book than can be used in conjunction with this one. Overall this book focuses primarily on the immune system elements. However there are many underlying genetic pathways that play a significant role and these are not considered in any detail. For example, the impact on the NF-kB pathway is significant as a promoter of cytokine production. I would assume that one should be aware of its function and impact. Overall this book is essential to have for anyone trying to do work in the current state of immunology. It provides the details and foundational elements that are invaluable. From this book one can jump quickly to the current literature.

la finalità del libro è rendere chiara una materia complessa ma fondamentale. Indispensabile per studenti in medicina e per medici non immunologi lo consiglio fortemente anche a specialisti immunologici per la completezza e la chiarezza della esposizione. Mi accingo ad accedere ai contenuti on Line e sono certo di restarne ulteriormente entusiasta. Riferirò

基礎免疫学のゴールデンスタンダードを、原著で学ぶ。 免疫学の進歩はすさまじく、ここ十数年で多くの分子標的治療薬が臨床応用されてきました。アレルギー・膠原病、さらには腫瘍学を専門とする医師でなくとも、これらの薬剤を目にする機会は増えていることでしょう。この書では、抗原抗体反応から複雑な免疫細胞のクロストークをクリアカット、かつ豊富なエビデンスに基づき記載されています。 第9版では免疫チェックポイント阻害薬、CAR-T療法など癌免疫の分野に関する最新の情報が組み込まれました。腫瘍専門医にとって免疫チェックポイント阻害薬は馴染みが深くなってきた治療ですが、CAR-T療法に馴染みのある方は少ないのでは。米国ではすでにCAR-T療法がFDA承認されており、腫瘍専門医としては理解を深めておきたいところです。

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